Jack Searle, an American widower, is bringing up his two stepdaughters Lidia and Marina alone in the border town of Laredo.
One night, Marina crosses the border into Mexico to go to a concert with her cousin Patricia in Nuevo Laredo – a dangerous city, controlled by drug cartels and devastated by violence and corruption. They never come back.
A frantic hunt begins, with Jack and inspector Gonzalo Soler leading the way. But soon the whole police force is suspended due to endemic corruption, the army takes over the city and the missing girls are forgotten. Jack and Gonzalo must take the law into their own hands, but in their efforts to find the girls they uncover truths about Nuevo Laredo that neither of them ever wanted to face.