Infectious Behavior : Brain-Immune Connections in Autism, Schizophrenia, and Depression - Patterson, Paul H.

Infectious Behavior : Brain-Immune Connections in Autism, Schizophrenia, and Depression

Paul H. Patterson

Yayınevi: MIT Press

Yayın tarihi: 10/2011

ISBN: 9780262016452

Ciltli | İngilizce | 176 Sayfa | 15,24x22,86x0,97 cm.

Tür: Sosyal Psikoloji

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In Infectious Behavior, neurobiologist Paul Patterson examines the involvement of the immune system in autism, schizophrenia, and major depressive disorder. Although genetic approaches to these diseases have garnered the lion's share of publicity and funding, scientists are uncovering evidence of the important communication between the brain and the immune system, and its involvement in mental illness. Patterson focuses on this brain-immune crosstalk, describing it both in healthy people and in those with mental disorders. The heart of the book concerns the involvement of the immune systems of a pregnant woman and her fetus, and a consideration of maternal infection as a risk factor for schizophrenia and autism. In the course of his discussion, Patterson takes up the currently hot topic of vaccinations and their connection to autism. After offering a short history of immune manipulation in treating mental illness--and recounting some frightening but fascinating early experiments--Patterson explains how the immune system influences behavior and how the brain regulates the immune system, looking in particular at stress and depression. He examines the role of immune cells and inflammatory molecules in fetal development and the relationship of the maternal immune system to the fetus; the prenatal origins of adult disease; the influence of the pregnant woman's infections on her offspring's mood, behavior, and disease; animal models of mental disorders; evidence for immune involvement in autism, schizophrenia, and depression; and the benefits and risks of pre- and postnatal vaccinations. Finally, Patterson discusses how to reduce the risk of fetal brain injury and examines the promise shown by recent animal experiments that have led to early clinical trials of postnatal and adult interventions that result in positive outcomes in patients with autism and schizophrenia.

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