Structure-Based Drug Discovery: An Overview (RSC Biomolecular Sciences) -

Structure-Based Drug Discovery: An Overview (RSC Biomolecular Sciences)

Yayınevi: Royal Society of Chemistry-RSC

Yayın tarihi: 03/2006

ISBN: 9780854043514

Ciltli | İngilizce | 270 Sayfa | 15,8x23,6x2,21 cm.

Tür: Kimya-Kimya Müh.

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This book is a collection of methods which exploit the ability to determine and analyse the three-dimensional structure of biological molecules. After an introductory overview of principles and applications of structure-based methods, the book examines X-ray crystallography, NMR spectroscopy, computational chemistry and molecular modelling, with discussions on developments such as high-throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening, and fragment-based drug discovery. Concluding chapters present case histories.

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